ISP Councillor
Orlov, Sergei N.    PhD, Dr.Biol.Sci.

Professor

Address for correspondence: Prof. Sergei N Orlov, Centre de Recherche (CHUM) Technopôle ANGUS, 2901 Rachel East Street – Room 313, Montreal, PQ, H1W 4A4, Canada; phone: 1-514-890-8000 ext 23615; fax: 1-514-412-7638; e.mail: sergei.n.orlov@umontreal.ca

Present position: Professor of Medicine, Faculty of Medicine and Head, Laboratory of Pathophysiology of Ion Transport Disorders, Research Centre, University of Montreal Hospital (CHUM) Montreal, PQ, Canada; Professor of Biophysics and Head, Laboratory of Physical Chemistry of Biomembranes, Faculty of Biology, MV Lomonosov Moscow State University; Russia

Honours: Diploma from the Scientific Committee of The Council of Ministries of the USSR; Academician, Russian Academy of Natural Sciences; Vice-President, Russian Society of Experimental Medicine; Pfizer Award from International Society on Hypertension; Senior Scholar of Servier Canada; Fellowships from American Heart Association, Council for High Blood Pressure

Member of the Editorial Board: Pulmonology; J.Hypertension; Arterial Hypertension; Recent Patents on Cardiovascular Drug Discovery; Recent Patents on Anti-cancer Drug Discovery

Most significant contributions: First documentation of cooperative interaction of unsaturated fatty acids with serum albumin (1976); Discovery of abnormal ion transport across plasma membranes in primary hypertension (1975-1977), Application of diS-C3-(5) for the study of conformational transitions of Ca2+-binding proteins (1984); first description of light-dependent Na+/Ca2+ exchanger in retinal rod discs (1989); Discovery of volume-dependent regulation of respiratory burst in neutrophils (1993); First description of volume-sensitive ion transporters in vascular smooth muscle cells (1992-1996); Demonstration of a key role of cytoskeleton in the inhibition of Na+,K+,Cl- cotransport (1995) and L-type Ca2+ channels (1996) by cAMP signaling; Demonstration of the distinct mechanisms of the involvement of cardiac glycosides in the regulation of apoptotic (2000) and necrotic (2003) mode of cell death; Disovery of novel Na+i-mediated Ca2+i-independent mechanism of the excitation-transcription coupling (2002).

Current research projects: Genetic and molecular determinants of abnormalities of ion transport in hypertension; Search for cell volume and monovalent ion sensors; Role of ion transporters and cell volume modulation in cell prolferation and death

Personal research support: the Canadian Institutes of Health Research; the Heart and Stroke Foundation of Canada; the Kidney Foundation of Canada; the Natural Sciences and Engineering Research Council of Canada



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