Dr. Zhang Youyi was granted her Ph.D. in Xinjiang Medical University in 1992. She worked in Institute of Vascular Medicine at Peking University Third Hospital as a post-doctoral fellow between 1992 and 1994. She worked as a Post doctornal at the Department of Pharmacology, Emory University, USA from 1999 to 2001. Dr. Zhang is now professor and Associate Director of Institute of Vascular Medicine and the Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education. She also are editors of Acta Physiologica Sinica, Chinese Journal of Pharmacology and Toxicology, etc.
As a principle investigator, she was in charge of more than ten grants including ‘973’ sub-projects that were organized by National Science and technology Department, grants from the National Natural Science Foundation of China. Dr. Zhang has more than one hundred publications.
Since 1993, Dr. Zhang’s research has been focused on adrenoceptors and cardiovascular disease, especially on distribution, expression, mediated biological function, signal transduction, regulation, cross-talk between adrenoceptors, and pathophysiological alterations of adrenoceptors in heart and blood vessels. Recently she started to work on study of the net-work control and integrity of signalings of the cardiac adrenoceptors as well as single molecular imaging detection in living cells.
Dr. Zhang was elected Secretary General at the 5th ISP Congress in Beijing.
Research Interests
- Physiological and pathophysiological significance of co-existence of three subtypes of a1-adrenoceptor in heart and blood vessels
- Network control and integrity of cardiovascular remodeling
- Single molecule study on adrenoceptors in living cells
- Drug screening of adrenoceptor subtypes
Publications
- You-Yi Zhang, Kai-Ming Xu and Chide Han. a1-Adrenoceptor Subtypes Mediating Inotropic Responses in Rat Heart The Journal of Pharmacology and Experimental Therapeutics, 1999, 291:829-836 (IF 3.051)
- Zhang Y, Lu Z, Ku L, Chen Y, Wang H, Feng Y. Tyrosine phosphorylation of QKI mediates developmental signals to regulate mRNA metabolism. EMBO J. 2003 Apr 15;22(8):1801-10 (IF 10.698)
- Zhang YY and Feng Y. Distinctive molecular mechanisms leads to diminished myelin basic protein and 2,3-cyclic nucleotide 3-phosphodiesterase in qkv dysmyelination. J Neurochem. 2001， 76：1-9 (IF 4.9)
- Feng Yin, Ping Li, Ming Zheng, Li Chen, Qi Xu, Kai Chen, Yong-yu Wang, You-yi Zhang#, and Chide Han. Intereleukin-6 Family of Cytokines Mediates Isoproterenol-Induced Delayed STAT3 Activation in Mouse Heart. The Journal of Biological Chemistry, 2003 23:21070-21075 (IF 6.696）
- Li P, Li J, Feng X, Li Z, Hou R, Han C, Zhang Y#. Gene expression profile of cardiomyocytes in hypertrophic heart induced by continuous norepinephrine infusion in the rats. Cell Mol Life Sci. 2003 Oct;60(10):2200-9 (IF 5.259)
- Wenqiang Liao, Shuyi Wang, Chide Han and Youyi Zhang#. 14-3-3 Protein regulate glycogen synthase 3b phosphorylation and inhibit cardiomyocyte hypertrophy. FEBS J 272 (2005) 1845-1854 SCI (IF 3.26)
- Wang J1*, Xu N2*, Feng X2, Hou N1, Zhang J1, Cheng X1, Chen Y2, Zhang Y2**, Yang X1**. Targeted Disruption of Smad4 in Cardiomyocytes Results in Cardiac Hypertrophy and Heart Failure. Circ Res. 2005 Oct 14;97(8):821-8. (IF 9.972)
- Jianhai Du, Wenqiang Liao, Yongyu Wang, Chide Han and Youyi Zhang* Inhibitory effect of 14-3-3 proteins on serum-induced proliferation of cardiac fibroblasts。European Journal of Cell Biology 2005, 84:843-852 (IF 2.312)
- Du JH, Xu N, Song Y, Xu M, Lu ZZ, Han C, Zhang YY#. AICAR stimulates IL-6 production via p38 MAPK in cardiac fibroblasts in adult mice: A possible role for AMPK. Biochem Biophys Res Commun.. 2005 Dec 2;337(4):1139-44 (IF 2.97)
- Feng Yin*, Yong-Yu Wang*, Jian-Hai Du*, Chun Li, Zhi-Zhen Lu,Chide Han, You-Yi Zhang# Noncanonical cAMP Pathway and p38 MAPK Mediate β2-Adrenergic Receptor-induced IL-6 Production in Neonatal Mouse Cardiac Fibroblasts. JMCC 2006（in press） (IF4.198)
|
